Second season of 'Buckwild' in West Virginia will not air on MTV.
By James Montgomery
Shain Gandee
Photo: MTV
Source: http://www.mtv.com/news/articles/1705298/buckwild-shain-gandee-tribute-special.jhtml
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As often as Dropbox has been courting serious cloud storage users with Dropbox for Teams, it doesn't feel that the name reflects the company's loftier ambitions -- so it's giving the service a rebranding. Now called Dropbox for Business, it's pitched more directly at the suit-and-tie set. There's more than just talk involved in the new strategy, though. The shift also sees Dropbox build in identity management from five providers so that Dropbox users don't have to sign into the service if they're already logged in elsewhere: they can hop on to the corporate Active Directory service, for example and have Dropbox ready for action soon after. We doubt that the new moves by themselves will sway IT managers, but they may help would-be users who've been on the fence.
Filed under: Storage, Internet
Via: TechCrunch
Source: Dropbox (1), (2)
Source: http://www.engadget.com/2013/04/10/dropbox-for-teams-becomes-dropbox-for-business/
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Public release date: 10-Apr-2013
Share ] Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Estrogen and progesterone receptors, and the gene HER2 these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors.
"This is a continuing line of work with all evidence pointing toward the addition of the androgen receptor as potential target and useful marker in all of the major subtypes of breast cancer," says Jennifer Richer, PhD, investigator at the University of Colorado Cancer Center and co-director of the CU Cancer Center Tissue Processing and Procurement Core.
The finding of androgen receptors (AR) as a potential target in breast cancer is especially important in light of its prevalence in breast cancers that don't express other hormone receptor targets or have developed resistance to treatments that target estrogen dependence. Overall, approximately 77 percent of breast cancers are positive for AR, including 88 percent of cancers that are estrogen receptor positive, 59 percent of those that are HER2 positive, and 20-32 percent of triple negative breast cancers.
The study presented this week explores the ability of estrogen-positive (ER+) breast cancers to develop resistance to anti-estrogen drugs by potentially developing an alternative addiction to AR and hypothesizes that anti-androgen therapy, such as the drug enzalutamide (formerly MDV3100) as successful counters to breast cancers' evolution. First, Richer and colleagues used breast cancer tumor registries to discover that cancers with higher ratios of AR to ER protein had shorter time to relapse after anti-estrogen therapies. Cut off from their estrogen addition, these cancers may have turned to growth and survival via androgens instead.
The group then returned to the lab to explore the effects of anti-androgen therapies in cell lines and preclinical models.
"Remarkably, the anti-androgen drug enzalutamide had effects comparable to the anti-estrogen drug tamoxifen in breast cancer cells that expressed both ER and AR," Richer says. HER2 cell lines that were also AR+ showed promising responses as well.
"We are excited to move toward clinical trials of anti-androgen therapies in breast cancer," Richer says. "And this study shows that patients with a high AR/ER ratio who relapse while on estrogen targeting therapies might be good candidates for this kind of therapy."
###
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 10-Apr-2013 Share ] Contact: Garth Sundem
garth.sundem@ucdenver.edu
805-559-2023
University of Colorado Denver
Estrogen and progesterone receptors, and the gene HER2 these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors.
"This is a continuing line of work with all evidence pointing toward the addition of the androgen receptor as potential target and useful marker in all of the major subtypes of breast cancer," says Jennifer Richer, PhD, investigator at the University of Colorado Cancer Center and co-director of the CU Cancer Center Tissue Processing and Procurement Core.
The finding of androgen receptors (AR) as a potential target in breast cancer is especially important in light of its prevalence in breast cancers that don't express other hormone receptor targets or have developed resistance to treatments that target estrogen dependence. Overall, approximately 77 percent of breast cancers are positive for AR, including 88 percent of cancers that are estrogen receptor positive, 59 percent of those that are HER2 positive, and 20-32 percent of triple negative breast cancers.
The study presented this week explores the ability of estrogen-positive (ER+) breast cancers to develop resistance to anti-estrogen drugs by potentially developing an alternative addiction to AR and hypothesizes that anti-androgen therapy, such as the drug enzalutamide (formerly MDV3100) as successful counters to breast cancers' evolution. First, Richer and colleagues used breast cancer tumor registries to discover that cancers with higher ratios of AR to ER protein had shorter time to relapse after anti-estrogen therapies. Cut off from their estrogen addition, these cancers may have turned to growth and survival via androgens instead.
The group then returned to the lab to explore the effects of anti-androgen therapies in cell lines and preclinical models.
"Remarkably, the anti-androgen drug enzalutamide had effects comparable to the anti-estrogen drug tamoxifen in breast cancer cells that expressed both ER and AR," Richer says. HER2 cell lines that were also AR+ showed promising responses as well.
"We are excited to move toward clinical trials of anti-androgen therapies in breast cancer," Richer says. "And this study shows that patients with a high AR/ER ratio who relapse while on estrogen targeting therapies might be good candidates for this kind of therapy."
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-04/uocd-ans_1040613.php
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This is a series of Q&As with new, young and up-and-coming science, health and environmental writers and reporters. They ? at least some of them ? have recently hatched in the Incubators (science writing programs at schools of journalism), have even more recently fledged (graduated), and are now making their mark as wonderful new voices explaining science to the public.
Today we introduce you to Dani Grodsky (Twitter).
Hello and welcome to The SA Incubator. To start off, where are you from?
How did you get into science and how did you get into writing? And how did these two trajectories fuse into becoming a science writer?
Well, I started off from a very young age with a deep passion for science. Ever since elementary school, where I popped balloons filled with confetti to simulate the range of germs when you sneeze or tested which liquid made a submerged gummy bear expand, I feel in love with the journey of discovery that science fosters.
For the last three summers of high school I had the opportunity to do research at some of the country?s top universities (Cooper Union, Rockefeller University and NYU) in organic chemistry, cellular biology and visual perception. Around the same time, I also began tutoring students in a variety of math and science subjects. It was amazing to take part in building their connection to science and I was inspired to continue providing others, on a broader scale, with the opportunity to learn about the fascinating scientific ideas and innovations that are always evolving.
Once I came to Brown, I had the luck of taking a course at the beginning of my freshman year in which we read the works of contemporary authors who would subsequently do a live reading and Q&A with us. Throughout the semester, it struck me how writing empowers the author to instill a feeling or idea while at the same time organically allowing the reader to discover how he or she relates to the topic. It dawned on me that science writing would be the perfect outlet for me to spread my own passion and bridge the public with the scientific world.
Are you currently doing any form of science writing for a job or internship?
What do you see as the significance of the science communicators? role in society?
For a topic so crucially important, science can not and should not exist in a bubble for only those willing and able to derive meaning from esoteric descriptions. This is where the science communicator comes in- not only recounting such descriptions in more accessible terms to enable and promote understanding but, more importantly, leading members of the public to discover for themselves the significance, intrigue and ubiquitous impact of science.
How do you see the current and future science media ecosystem, how it differs from the past, and what role will new, young science communicators like yourself play in building it and making it the best it can be?
Today, story telling is being taken to new heights with the use of accompanying technology. As impactful as the written word can be in transmitting ideas, it will always be limited to the one dimensional surface ? captivating in so far as it can be dissected and processed. The use of multimedia and ceaselessly advancing technology adds a dimension that can more fully stimulate the senses and create a form of learning that reflects that of true experience.
What are your plans for the future?
One thing I am certain about is my continued pursuit as a science communicator. Ideally, this will take shape in the form of covering topics of the mind. I enter Brown with the strong conviction to study cognitive neuroscience and my fascination with how the brain shapes the totality of our perceptions and actions has remained unfading. More specifically, in my writing I want to further explore cognition as it relates to motivation, decision making and the emerging area of behavioral economics. Overall, I am excited to continue my pursuit of using reporting and story telling to incite discussion along with new or stronger connections to science.
Thank You!
Thanks to you as well! This has truly been great.
====================
Previously in this series:
Kristina Ashley Bjoran
Emily Eggleston
Erin Podolak
Rachel Nuwer
Hannah Krakauer
Rose Eveleth
Nadia Drake
Kelly Izlar
Jack Scanlan
Francie Diep
Maggie Pingolt
Jessica Gross
Abby McBride
Natalie Wolchover
Jordan Gaines
Audrey Quinn
Douglas Main
Smitha Mundasad
Mary Beth Griggs
Shara Yurkiewicz
Casey Rentz
Akshat Rathi
Kathleen Raven
Penny Sarchet
Amy Shira Teitel
Victoria Charlton
Noby Leong and Tristan O?Brien
Taylor Kubota
Benjamin Plackett
Laura Geggel
Daisy Yuhas
Miriam Kramer
Ashley Taylor
Kate Yandell
Justine Hausheer
Aatish Bhatia
Ashley Tucker
Jessica Men
Kelly Oakes
Lauren Fuge
Catherine Owsik
Marissa Fessenden
Mollie Bloudoff-Indelicato
Kelly Poe
Kate Shaw
Meghan Rosen
Jon Tennant
Ashley Braun
Suzi Gage
Michael Grisafe
Jonathan Chang
Alison Schumacher
Alyssa Botelho
Hillary Craddock
Susan Matthews
Lacey Avery
Ilana Yurkiewicz
Kate Prengaman
Nicholas St. Fleur
Source: http://rss.sciam.com/click.phdo?i=6011a5615b7d6a7cb3958baa47f9491c
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However just because you have declared bankruptcy, it doesn?t mean you?ll be ineligible to buy a home for the rest of your life. ?After a couple of years, you can again qualify. ?From?Tamara Schuster, a broker from Illinois,
FHA is available 2 years after Chapter 7 discharge ?( Bankruptcy) EXCEPT that if there is a foreclosure, the rule is 3 years after the foreclosure is complete ? meaning generally 3 years from the date of transfer of the deed to the next owner (could be a buyer or the bank if they hold the property).? So people with a foreclosure face a longer wait even if their credit has been reestablished.
If you are looking for a home, be completely truthful with your lender so they can tell you definitely whether you are qualified now or if you need to wait a few more months or another year.
Source: http://shakandjill.com/2013/02/you-can-buy-after-bankruptcy.html
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Realosophy Team in Top Ten Neighbourhoods, Toronto Real Estate News, Home Buying, Home Selling
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Want more analytics? Attend Our Next Realosophy Workshop: How School Quality Affects House Prices & Your Home Buying Strategy
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Heat Map: Toronto Neighbourhoods by House Price Appreciation, 2011 to 2012
Map Instructions: On upper right hand side of map, click on green tab on box to hide legend. On upper right hand side of map, click on box to expend legend.
Central Toronto Houses Hot
Seven of our top ten neighbourhoods are in central Toronto (west of DVP and east of Dufferin). In one half of the tale of two cities (the other being the gossamer that is Toronto's condoland), strong demand from urban families, coupled with a finite number of houses in central Toronto, means higher prices.
And in neighbourhoods offering detached houses or top schools, the appreciation is significant. The neighbourhoods on this list have appreciated 21% to 27%, well above the citywide appreciation rate of approximately 6%.
Almost one in four properties in Toronto sold for "over the asking price" in 2012 - a striking number as this is an indirect way to assess multiple offer activity. Half of the neighbourhoods on our list rated above the city average with 37-52% of properties selling "over asking."
Inner Burbs Rise
A handy catch-all, the ?urban family? actual encompasses several profiles. The New Urban (Nuburban?) family wants to ditch the commute, but not the detached house, larger lot and green lawns. This family sacrifices space, which they prize, and could buy more of in the outer suburbs, to gain time. These preferences are driving up prices in some inner burb (Etobicoke, North York, East York) neighbourhoods - see Islington Village, Parkwoods and Victoria Park Village on our list.
Luxury Redefined
The Established Urban family drives demand in upper-end neighbourhoods like Allenby, Caribou Park, Rathnelly and Casa Loma on our list. They value the pedigree of the neighbourhood, larger houses and local schools, rather than their urban features per se, but do appreciate excellent subway access and top quality main streets.
Long-standing luxury neighbourhoods - Forest Hill, Bridle Path and Teddington Park - start on higher ground so it's rare to see them on "best appreciation" lists - so while Forest Hill makes our list, it's important to note that a handful of super luxury sales can skew the average.
Urban Beauties
Core Urban families value the "urban" in urban living - diversity, access to bike lanes and public transit and walkable main streets. These preferences lead them to lead boldly in less economically established areas in very downtown locations, unfazed by the prospect of shared walls - think Dufferin Grove and Trinity Bellwoods on our list. These consumer preferences are at the core of Toronto?s urban revitalization trend of the past 10 years and counting, a period which may one day be seen as seminal in our city's history.
Understanding the Data
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1. Allenby (Central) See Current Houses for Sale in Allenby
Avg. Price 2012: $1,074,630
Avg. Price 2011: $846,534
Multiple Offer Activity: 52%
Housing Breakdown: 100% Detached
Walkability: 72/100
Popularity Points:
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Top Elementary Schools:
Top High Schools:
Full Neighbourhood Profile for Allenby
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2. Caribou Park (Central) See Current Houses for Sale in Caribou Park
Avg. Price 2012: $942,877
Avg. Price 2011: $745,408
Multiple Offer Activity: 17%
Housing Breakdown: 74% Detached, 26% Condos
Walkability: 63/100
Popularity Points:
Full Neighbourhood Profile for Caribou Park
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3. Islington Village (West) See Current Houses for Sale in Islington Village
Avg. Price 2012: $611,917
Avg. Price 2011: $490,361
Multiple Offer Activity: 9%
Housing Breakdown: 50% Condos, 43% Detached, 3% Condo Townhouse, 3% Row/Townhouse, 1% Other
Walkability: 38/100
Popularity Points:
Top Elementary Schools:
Top High Schools:
Full Neighbourhood Profile for Islington Village
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4. Dufferin Grove (Central) See Current Houses for Sale in Dufferin Grove
Avg. Price 2011: $703,408
Multiple Offer Activity: 54%
Housing Breakdown: 48% Semi-Detached, 28% Detached, 12% Row/Townhouse, 10% Condo Townhouse, 2% Condos
Walkability: 92/100
Popularity Points:
Top Elementary Schools:
Top High Schools:
Full Neighbourhood Profile for Dufferin Grove
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5. Forest Hill (Central) See Current Houses for Sale in Forest Hill
Avg. Price 2011: $1,054,733
Multiple Offer Activity: 17%
Housing Breakdown: 56% Detached Houses, 27% Condos, 12% Co-Op, 3% Semi-Detached, 2% Row/Townhouse
Walkability: 63/100
Popularity Points:
Top Elementary Schools:
Top High Schools:
Full Neighbourhood Profile for Forest Hill
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6. Rathnelly (Central) See Current Houses for Sale in Rathnelly
Avg. Price 2011: $710,149
Multiple Offer Activity: 18%
Housing Breakdown: 57% Condos, 39% Semi-Detached, 5% Detached
Walkability: 83/100
Popularity Points:?
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Top Elementary Schools:
Full Neighbourhood Profile for Rathnelly
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7. Trinity Bellwoods (Central) See Current Houses for Sale in Trinity Bellwoods
Avg. Price 2011: $656,268
Multiple Offer Activity: 41%
Housing Breakdown: 40% Row/Townhouse, 32% Semi-Detached, 17% Detached, 6% Condo Townhouse, 5% Condos
Walkability: 90/100
Popularity Points:
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Full Neighbourhood Profile for Trinity Bellwoods
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8. Casa Loma (Central) See Current Houses for Sale in Casa Loma
Avg. Price 2011: $968,437
Multiple Offer Activity: 37%
Housing Breakdown: 50% Detached, 23% Row/Townhouse, 17% Condo Townhouse, 10% Semi-Detached
Walkability: 80/100
Popularity Points:
9. Parkwoods (Central) See Current Houses for Sale in Parkwoods
Avg. Price 2011: $454,074
Multiple Offer Activity: 39%
Housing Breakdown: 46% Detached, 33% Semi-Detached, 19% Condos, 1% Condo Townhouse, 1% Other
Walkability: 67/100
Popularity Points:Top Elementary Schools:
Top High Schools:
?Full Neighbourhood Profile for Parkwoods
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10. Victoria Park Village (Central) See Current Houses for Sale in Victoria Park Village
Avg. Price 2012: $428,406
Avg. Price 2011: $355,028
Multiple Offer Activity: 19%
Housing Breakdown: 38% Detached, 37% Condos, 13% Semi-Detached, 9% Condo Townhouse,? 3% Row/Townhouse, 1% Other
Walkability: 65/100
Popularity Points:?Full Neighbourhood Profile for Victoria Park Village
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Sign up for Realosophy's Schools for Home Buyers Workshop
Realosophy Realty Inc. Brokerage is an innovative residential real estate brokerage in Toronto. A leader in real estate analytics and pro-consumer advice, Realosophy helps clients buy or sell a home the right way.?Email Realosophy
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SAN QUENTIN, California (Reuters) - One by one, the entrepreneurs, clad in crisp blue jeans and armed with PowerPoint presentations, stood before a roomful of investors and tech bloggers to explain their dreams of changing the world.
For these exuberant times in Silicon Valley, the scene was familiar; the setting, less so.
With the young and ambitious flocking again to northern California to launch Internet companies, there were signs one recent morning that startup mania has taken hold even behind the faded granite walls of California's most notorious prison.
"Live stream has gone mainstream. Mobile video usage went up and is expected to increase by 28 percent over the next five years," said Eddie Griffin, who was pitching a music streaming concept called "At the Club" and happens to be finishing a third stint for drug possession at San Quentin State Prison, near San Francisco, after spending the last 15 years behind bars.
Griffin was one of seven San Quentin inmates who presented startup proposals on "Demo Day" as part of the Last Mile program, an entrepreneurship course modeled on startup incubators that take in batches of young companies and provide them courses, informal advice and the seed investments to grow.
According to business news website Xconomy, incubator programs - which it tracks - have tripled in number for each of the past three years, proliferating from Sao Paulo to Stockholm at a pace that has fueled talk in tech circles of an "incubator bubble".
Last Mile founder Chris Redlitz, a local venture capitalist, says his goal was never to seek out a genuine investment opportunity inside a prison but to educate inmates about tech entrepreneurship and bridge the knowledge gap between Silicon Valley's wired elite and the rest of the region's population.
Inmates, after all, are not allowed to run businesses. They do not have access to cellphones ? much less Apple Inc's latest iPhone developer toolkits ? and they use computers only under close supervision.
A LOT TO LEARN
After his presentation in San Quentin's chapel, which received a rousing reception from an audience that included prison warden Kevin R. Chappell, Griffin told a reporter it was unlikely he would launch his startup idea immediately after being released this summer.
"I still have a lot to learn," said the soft-spoken Detroit native. "I've never used a cellphone. Technology is kind of foreign in this environment."
But to hear the inmates use jargon such as "lean startup" and "minimum viable product" speaks to an unmistakable truth about the Bay Area zeitgeist, where startups, for better or worse, have come to embody upward mobility, ambition, and hustle.
"If they were doing this in the '80s there may have been a different theme or model," said Wade Roush, Xconomy's chief correspondent. "But in this day and age, becoming an entrepreneur or starting a business is a form of self-actuation."
Situated on prime waterfront land, San Quentin is perhaps California's most storied prison and home to the state's only death row. But it has also kept a longstanding progressive reputation, boasting a rare college degree-granting program and vibrant arts courses.
The Last Mile accepted 10 inmates out of 50 applicants for its latest batch. The program, which graduated its first class of inmates last year, meets twice a week to discuss startups and lasts six months, although the most recent class took seven months due to a prison lockdown last year.
Some Last Mile participants, under official supervision, have also joined the online question-and-answer site Quora to respond to questions about prison life or describe what it felt like to commit murder.
The latest batch of startup ideas included a fitness app that would motivate drug addicts to exercise, a cardiovascular health organization, a social network for sufferers of post-traumatic stress disorder, a food waste recycling program, and an e-commerce site for artists in prison.
DIFFERENT PERSPECTIVE
Because the likelihood is not great that these companies will become funded and succeed, Redlitz said he was also working to place the inmates in jobs at tech companies after their release.
Rocketspace, a startup co-working space in downtown San Francisco, has agreed to host an internship. Rally.org, a crowd-funding site that counts Redlitz among its investors, said it hoped to begin a program to seek micro-investments from the public for the inmates' ideas.
Sitting in the Demo Day audience was John Collison, the 22-year-old co-founder of online payments startup Stripe, who noted some stark differences between the inmates' proposals and the fashionable startups du jour in Silicon Valley.
"What's frustrating is that all these companies in the Valley, they're ideas for the 1 or 10 percent," Collison said. "You have startups like Uber or Taskrabbit, that's like, ?Oh, here's something to help you find a driver or find someone to clean your house.' Are they solving real problems?"
The San Quentin inmates "were talking about urban obesity, or PTSD", Collison said. "It's a completely different perspective. We actually really need that."
(Reporting by Gerry Shih; Editing by Dale Hudson)
Source: http://news.yahoo.com/inmates-high-tech-startup-mania-hits-san-quentin-140717846--sector.html
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